• Results of the present study demonstrate that OHC treatment

  2020-11-20

  

  Results of the present study demonstrate that 25-OHC treatment of THP-1 monocytes induced vimentin intermediate filament reorganization to more cortical structures and a polarized phenotype (Fig. 5). Vimentin is the major intermediate filament protein present in leukocytes and plays an important rol

• The kinase activity of DNA

  2020-11-20

  

  The kinase activity of DNA-PKcs is essential for NHEJ, but the exact role of the enzymatic activity of DNA-PKcs plays in NHEJ is not fully understood [57]. In vitro, DNA-PKcs can phosphorylate each of the canonical NHEJ factors including Ku70/80 [58], [59], XRCC4 [60], [61], 3'-Azido-3'-deoxythymidi

• ARM1 In this report we evaluate if this molecular mechanism

  2020-11-20

  

  In this report, we evaluate if this molecular mechanism is used universally by high-fidelity DNA polymerases during the replication of DNA lesions that are structurally distinct from abasic sites. This was approached by quantifying the kinetic parameters for the incorporation of modified and non-nat

• Diacylglycerol kinase was one of the

  2020-11-20

  

  Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a Superoxide Dismutase (SOD) Activity Assay Kit of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns an

• The aniline R group was extensively explored and a

  2020-11-19

  

  The aniline R2 group was extensively explored and a large variety of substitution was tolerated at several positions on the aryl ring (). Notably, substitution at the 3-position often gave increased potency. Increasing lipophilic bulk at this position gave increasing potency within an ether series (

• br Four active site residues of KSTD are fully

  2020-11-19

  

  Four active site residues of Δ1-KSTD1 are fully conserved in Δ1-KSTDs from different species (Supplementary Figure S2). These residues are Tyr-119, Tyr-487, and Gly-491 from the FAD-binding domain and Tyr-318 from the catalytic domain. The structure of the Δ1-KSTD1•ADD complex revealed that the hy

• DDR plays a crucial role in regulating a

  2020-11-19

  

  DDR2 plays a crucial role in regulating a wide variety of fundamental cellular processes, including cell proliferation, differentiation, and adhesion [17], [28], [29], [30]. The authors revealed compromised cell migration in DDR2-silenced fibroblasts exposed to Ang II, most likely due to the loss of

• br Materials and methods br Results br Discussion

  2020-11-19

  

  Materials and methods Results Discussion Our study assessed the cytokine and chemokine changes associated with first onset PP as compared to HP and HNP groups. In the monocytes/ macrophages/ dendritic Nitidine chloride panel, IL-6 levels were found to be significantly elevated in both HP an

• Proteins that associate to PCNA are characterized by having

  2020-11-19

  

  Proteins that associate to PCNA are characterized by having conserved motifs as the PCNA-interacting protein (PIP) motif [29,30], its variant PIP-like motif [31,32] or the APIM motif (Alk B homologue 2 PCNA interacting motif [33,34]); for instance, p21 contains a PIP motif [30], and DNA polymerases

• br Materials and methods br Results and discussion In the

  2020-11-19

  

  Materials and methods Results and discussion In the present work, we have applied two methodologies, CoMFA and CoMSIA to build 3D-QSAR models. There is no crystal structure available; therefore, an indirect method i.e., a ligand-based approach is the method of choice. The highly active molecul

• br Using the same sort of methods

  2020-11-19

  

  Using the same sort of methods, we can also address the proof of Theorem 1.2. The first part of the proof is made much easier if we use the “sieving” construction. Concretely, given a CMV operator , let denote the CMV operator with This induces a simple change in the spectrum; namely, if denotes t

• In the horse oviduct the EP receptor was most

  2020-11-18

  

  In the horse oviduct, the EP2 receptor was most strongly expressed in epithelial Imipramine hydrochloride particularly in nonciliated (secretory) epithelial cells as evidenced by IHC. Furthermore, relative amount of EP2 mRNA was greater in the ampulla than in the isthmus, although this likely refle

• br Effects of culture conditions on drug induced

  2020-11-18

  

  Effects of culture conditions on drug-induced gene p2x receptors in primary human hepatocytes Past progress in elucidating the optimal conditions for the long-term cultivation of rodent hepatocytes has helped define some of the key components in the matrix and medium environment that are most cr

• The component E of PDHc PDHc

  2020-11-18

  

  The component E1 of PDHc (PDHc-E1) catalyzes the first step of multistep processes, using thiamine diphosphate (ThDP) and Mg2+ as cofactors.15, 16 Especially, this PDHc-E1 catalyzed process is a rate limiting step among multistep processes. Accordingly, the PDHc should be inactive by inhibiting the

• UBA belongs to the non

  2020-11-18

  

  UBA5 belongs to the non-canonical E1 enzymes that lack a defined Cys domain but have the active-site Cys within the adenylation domain [24]. Similar to other E1 enzymes, UBA5's adenylation domain comprises an eight-stranded beta sheet that is surrounded by helices [21]. Moreover, like the ancestral

15296 records 788/1020 page Previous Next First page 上5页 786787788789790 下5页 Last page