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br Materials and methods br
2021-01-05

Materials and methods Results Discussion Cells in the human body, especially in the cardiovascular and musculoskeletal systems, undergo a variety of mechanical stimuli. In order to ensure human movement, the strength of stretching muscles acts on cartilage and bone, moving joints through te
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orthopox Traditionally serum triglycerides have been measure
2021-01-04

Traditionally, serum triglycerides have been measured in the clinic in the fasted state in order to reduce variability and also to facilitate the calculation of LDL-cholesterol via the Friedewald equation, which was derived using fasted samples (Warnick and Nakajima, 2008). We have previously report
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Although elevated production of cysLTs
2021-01-04

Although elevated production of cysLTs is characteristic of rhinosinusitis of diverse etiology, patients with aspirin-sensitive rhinosinusitis show even higher levels of cysLTs in the nasal mucosa, which are further enhanced by aspirin challenge., Elevated production of cysLTs in these patients may
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In present study we measured the methylation and expression
2021-01-04

In present study, we measured the methylation and carboxypeptidase b levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation is
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Investigations of mice lacking up
2021-01-04

Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other Capreomycin Sulfate australia regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13. Mouse mo
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Pyridostatin br Progestogens and venous thromboembolism clin
2021-01-04

Progestogens and venous thromboembolism: clinical data Progestogens and haemostatis: biological studies For many years, the effect of HT on haemostatis has been largely investigated in observational studies as well as in high evidence level studies among users of oral and transdermal estrogens
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Finally we demonstrated for the
2021-01-04

Finally, we demonstrated for the first time that the physiological combinations of estradiol and progesterone levels of premenopausal and postmenopausal women efficiently stimulated the growth of T47D spheroids while clinically relevant concentrations of TPA and UPA suppressed the growth of T47D sph
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The nuclear receptor NR superfamily of
2021-01-04

The nuclear receptor (NR) superfamily of ligand regulated transcription factors has proven to be a rich source of targets for the development of therapeutics for a wide range of human diseases. The NR3B subfamily known as the estrogen-related receptor (ERRα[NR3B1], ERRβ[NR3B2] and ERRγ[NR3B3]) regul
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Another clinical study indicated the daily consumption of gr
2021-01-04

Another clinical study indicated the daily consumption of green tea with low concentrations of theanine and catechin would improve cognitive function (Ide et al., 2014). Further, in a double blind randomized clinical study involving 102 patients, the Hypericum extract was examined in terms of effica
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br Conclusion Our study demonstrates that the effects
2021-01-04

Conclusion Our study demonstrates that the effects of Epac activation are strongly conditioned by the steady-state Ca levels at which the myocyte is functioning. As intracellular Ca increases, the activity of CaMKII enhances and the phosphorylation of its SR substrates acquires different relevanc
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The histologic finding that EBV infected B
2020-12-31

The histologic finding that EBV-infected CPI-203 in infectious mononucleosis tend to avoid the GCs and instead accumulate under the epithelium of certain mucosal tissues34, 129 could be explained by the above-mentioned expression patterns of chemokine receptors on EBV-infected B cells. CXCR4 and CXC
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Eggs have been recognized as an important contributor of
2020-12-31

Eggs have been recognized as an important contributor of functional ingredients for humans [3]. Egg yolk is composed of various biologically active proteins. The water-soluble proteins of egg yolk have been examined for their functional effects on longitudinal bone growth during the growth period in
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As small non coding RNAs microRNAs miRNAs
2020-12-31

As small non-coding RNAs, microRNAs (miRNAs) can control gene expression at the post-transcriptional level by binding to the 3′-untranslated regions (3′-UTR) of messenger RNAs (mRNA) [15], [16]. miRNAs have been anticipated to regulate virtually all cellular mechanisms [17] and to play an important
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br DAG kinase activity is confined to specific cell
2020-12-31

DAG kinase activity is confined to specific cell compartments A number of reports demonstrating agonist-dependent translocation of DGKs to distinct membrane compartments suggest that DGK activity is restricted to localized DAG pools generated after activation of receptors. Perhaps the best eviden
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The first example of a broadly acting antiviral drug is
2020-12-31

The first example of a broadly-acting antiviral drug is ribavirin, a nucleoside analogue that was proposed to act directly at the level of the viral polymerase, although an indirect effect via inhibition of the host-cell IMP dehydrogenase and depletion of the GTP pool seems more plausible [9]. Anoth
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