• BGJ398 (NVP-BGJ398): Precision FGFR Inhibition in Oncolog...

  2025-09-26

  Explore the scientific depth of BGJ398 (NVP-BGJ398), a selective FGFR1/2/3 inhibitor, as an advanced tool for cancer research and targeted apoptosis induction. This article uniquely bridges receptor tyrosine kinase inhibition with emerging developmental biology insights and clinical oncology applications.

• Cy5-UTP: Next-Gen Fluorescent RNA Labeling for Intracellu...

  2025-09-25

  Discover how Cy5-UTP (Cyanine 5-uridine triphosphate) advances fluorescent RNA probe synthesis and unlocks new insights into intracellular trafficking and delivery efficiency. This article uniquely connects molecular labeling with delivery system optimization for superior molecular biology research.

• ARCA Cy5 EGFP mRNA (5-moUTP): Next-Gen Reporter for Preci...

  2025-09-24

  Explore how ARCA Cy5 EGFP mRNA (5-moUTP), a 5-methoxyuridine modified and fluorescently labeled mRNA, sets a new benchmark for mRNA localization and translation efficiency assays. This article uniquely examines its role in dissecting delivery barriers and immune modulation in mammalian cell studies.

• Advancing mRNA Research: EZ Cap Cy5 Firefly Luciferase mR...

  2025-09-23

  Explore how EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP) leverages 5-moUTP modification and Cap1 capping to improve mRNA stability, translation efficiency, and innate immune suppression in mammalian systems. This article provides new technical insights and practical strategies for optimizing mRNA delivery and reporter assays in advanced research applications.

• Flow cytometry antibody The PAS domains of AHR consist of tw

  2025-03-03

  

  The PAS domains of AHR consist of two regions, PAS-A and PAS-B, which function as interfaces for dimerization with ARNT and for ligand binding, respectively [14]. Although both the bHLH and the PAS-A domains have been shown to be involved in dimerization with ARNT, a recent report suggests that only

• In the search for more specific inhibitors of uptake Iversen

  2025-03-03

  

  In the search for more specific inhibitors of uptake2, Iversen and Salt (1970) speculated that steroids may potentiate the actions of catecholamines on vascular smooth muscle by inhibiting uptake2-mediated catecholamine clearance of the transmitters. They went on to demonstrate that a variety of ste

• br Introduction Myasthenia gravis MG is an autoimmune diseas

  2025-03-03

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease characterised by failure of transmission at the neuromuscular junction (NMJ). In 80–85% of myasthenia gravis patients, the disease is mediated by antibodies to the nicotinic EZ Cap p53 receptor (AChR; (Lindstrom et al., 1976). Many inv

• The subdivision of HT receptors started in the s

  2025-03-03

  

  The subdivision of 5-HT receptors started in the 1950s by Gaddum and colleagues, when they realised that in the guinea pig ileum, the effects of 5-HT could be blocked in part by morphine (M), and in part by dibenzyline (D). Gaddum and Picarelli proposed two receptor classes, 5-HT M and 5-HT D (1957)

• In this paper we described synthesis biological evaluation a

  2025-03-01

  

  In this paper, we described synthesis, biological evaluation and docking study of 3-aroyl-1-(4-sulfamoylphenyl)thiourea derivatives 4a–o as 15-lipoxygenase inhibitors. Results and discussion Conclusion We designed and synthesized a novel of thiourea derivatives containing phenylsulfonamide mo

• As a neuropeptide Apelin also has a critical role in

  2025-03-01

  

  As a neuropeptide, Apelin also has a critical role in cardiovascular diseases. Systemic administration of Apelin exert vasodilatory and antihypertensive effects [33]. Meanwhile, the apelin-APJ signal transduction pathway is related to age-associated cardiovascular diseases [34]. It has been known th

• Weak and transient interactions of HMGB proteins

  2025-03-01

  

  Weak and transient interactions of HMGB proteins in such hit-and-run mechanisms are understandable given that “fluorescence loss in photobleaching” (FLIP) experiments employing GFP-labeled HMGBs have shown that in living cells they are the most mobile of all nuclear proteins [144]. The entire pool o

• br Conclusions In summary we report a novel

  2025-03-01

  

  Conclusions In summary, we report a novel preliminary finding of a potential racial difference in the association of Cd-content and AR expression in prostate cancer that will need to be confirmed in larger studies. Although the association of Cd and AR protein expression is not strong in tumor ti

• Recent genome wide association studies have indicated SORL

  2025-03-01

  

  Recent genome-wide association studies have indicated SORL1 as a risk factor for AD (Meng et al., 2007, Rogaeva et al., 2007, Wen et al., 2013). SORL1, is expressed in neurons (Yin et al., 2015) and also regulates APP traffic from the cell membrane to the Golgi apparatus. A reduction in its expressi

• One of the specifications of the

  2025-03-01

  

  One of the specifications of the NIA-AA research framework was that it PD 173074 be applicable in two distinct research contexts—interventional trials and observational research. In many if not most modern AD interventional trials, individuals are selected for inclusion with the aid of biomarkers.

• Unexpectedly under pathological pain conditions inhibition

  2025-03-01

  

  Unexpectedly, under pathological pain conditions, inhibition of spinal glutamate transporter activity can produce antinociceptive effects. For example, intrathecal injection of the transportable inhibitor trans-pyrrolidine-2,4-dicarboxylic Acitretin (t-PDC) or antisense oligonucleotides reduced noc

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